宫外孕2号方合失笑散加味联合米非司酮在异位妊娠保守治疗中的作用(1)

http://www.100md.com 2019年11月15日 《中外医学研究》 201932

     【摘要】 目的：探究给予异位妊娠保守治疗患者宫外孕2号方合失笑散加味联合米非司酮的临床效果。方法：回顾性纳入2015年12月31日-2018年12月31日实施宫外孕2号方合失笑散加味联合米非司酮的异位妊娠患者43例的临床资料作为研究组，同期选取实施米非司酮的异位妊娠患者43例的临床资料作为对照组。观察两组临床疗效及血清β-hGG、孕酮水平。结果：研究组治疗总有效率为95.35%，高于对照组的79.07%，差异有统计学意义(P<0.05);研究组治疗后第7天血清β-hGG及孕酮水平下降幅度均较对照组明显，差异均有统计学意义(P<0.05);研究组血清β-hGG及孕酮水平下降至正常时间均短于对照组，差异均有统计学意义(P<0.05)。结论：宫外孕2号方合失笑散加味联合米非司酮在异位妊娠保守治疗中可有效加快血清β-hGG及孕酮水平下降幅度，缩短血清β-hGG及孕酮水平下降至正常时间，提高临床疗效。

    【关键词】 异位妊娠 米非司酮 中医

    doi：10.14033/j.cnki.cfmr.2019.32.056 文献标识码 B 文章编号 1674-6805(2019)32-0-02

    [Abstract] Objective： To study the clinical effect of Gongwaiyun Prescription Ⅱ and modified Shixiaosan combine with Mifepristone in the conservative treatment of ectopic gestation. Method： The clinical data of 43 ectopic gestation patients who received Gongwaiyun Prescription Ⅱ and modified Shixiaosan combine with Mifepristone from December 31， 2015 to December 31， 2018 were retrospectively included as the study group， and the clinical data of 43 ectopic gestation patients treated with Mifepristone were selected as the control group. The clinical effect， levels of serum β-hGG and progesterone were investigated between the two groups. Result： The total effective rate in the study group was 95.35%， which was higher than 79.07% of the control group， and the difference was statistically significant (P<0.05). On the 7th day after treatment， the descend range of serum β-hGG and progesterone in the study group were significantly than those of the control group， and the differences were statistically significant (P<0.05). Levels of serum β-hGG and progesterone dropped to normal time in the study group were shorter than those of the control group， and the differences were statistically significant (P<0.05). Conclusion： Gongwaiyun Prescription Ⅱ and modified Shixiaosan combine with Mifepristone can effectively accelerate the descend range of serum β-hGG and progesterone levels， shorten serum β-hGG and progesterone drop to normal time， and increase the clinical effect.

    [Key words] Ectopic gestation Mifepristone TCM

    First-author’s address： Heyuan Hospital of Traditional Chinese Medicine， Heyuan 517000， China

    異位妊娠临床治疗手段包括手术治疗和保守治疗，但手术治疗存在一定创伤性，医疗费用较高，且手术后易出现并发症[1]。保守治疗可以避免手术造成的损伤及并发症，恢复期短，尤其适合有生育要求的患者[2]。异位妊娠药物保守治疗中包括中药治疗、西药治疗及中西结合治疗。近年来，中西结合治疗受到临床医生的青睐[3-4]。因此，本研究对宫外孕2号方合失笑散加味联合米非司酮在异位妊娠保守治疗中的临床效果进行分析，报道如下。

    1 资料与方法

    1.1 一般资料

    回顾性纳入2015年12月31日-2018年12月31日实施宫外孕2号方合失笑散加味联合米非司酮的异位妊娠患者43例的临床资料作为研究组。同期选取实施米非司酮的异位妊娠患者43例的临床资料作为对照组。研究组年龄19～40岁，平均(28.65±5.98)岁;停经时间30～100 d，平均(51.87±10.68)d;, 百拇医药(袁秋云)

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